Table 3.
Odds Ratios (ORs) and 95% Confidence Intervals (CIs) for the Association Between Single Nucleotide Polymorphisms (SNPs) on AURKA and Subtype of Breast Cancer
SNP | Luminal A (Ncases = 674)
|
Luminal B (Ncases = 114)
|
HER2+/ER− (Ncases = 94)
|
Basal-like (Ncases = 199)
|
Unclassified (Ncases = 129)
|
|||||
---|---|---|---|---|---|---|---|---|---|---|
ORa (95% CI) | Padj b | ORa (95% CI) | Padj b | ORa (95% CI) | Padj b | ORa (95% CI) | Padj b | ORa (95% CI) | Padj b | |
rs1047972 | ||||||||||
AG + AA | 0.96 (0.78, 1.18) | 0.90 | 0.75 (0.48, 1.18) | 0.87 | 0.84 (0.52, 1.36) | 0.90 | 1.34 (0.97, 1.85) | 0.76 | 0.93 (0.62, 1.40) | 0.90 |
GG | Referent | Referent | Referent | Referent | Referent | |||||
rs1468056 | ||||||||||
CG + CC | 1.28 (1.03, 1.59) | 0.38 | 1.06 (0.68, 1.64) | 0.95 | 1.04 (0.64, 1.70) | 0.96 | 1.13 (0.78, 1.63) | 0.90 | 0.90 (0.58, 4.41) | 0.90 |
GG | Referent | Referent | Referent | Referent | Referent | |||||
rs16979826 | ||||||||||
CT + CC | 0.81 (0.54, 1.21) | 0.90 | 0.69 (0.28, 1.72) | 0.90 | 2.14 (1.06, 4.29) | 0.41 | 0.88 (0.51, 1.50) | 0.90 | 1.18 (0.65, 2.15) | 0.90 |
TT | Referent | Referent | Referent | Referent | Referent | |||||
rs16979829 | ||||||||||
GT + GG | 0.92 (0.69, 1.23) | 0.90 | 0.97 (0.54, 1.77) | 0.96 | 1.05 (0.57, 1.92) | 0.96 | 1.22 (0.82, 1.82) | 0.90 | 1.03 (0.63, 1.69) | 0.96 |
TT | Referent | Referent | Referent | Referent | Referent | |||||
rs16979865 | ||||||||||
CA + CC | 1.20 (0.93, 1.55) | 0.79 | 0.71 (0.39, 1.31) | 0.90 | 1.01 (0.56, 1.82) | 0.98 | 0.91 (0.59, 1.41) | 0.90 | 1.05 (0.64, 1.73) | 0.96 |
AA | Referent | Referent | Referent | Referent | Referent | |||||
rs2180691 | ||||||||||
AG + AA | 0.96 (0.77, 1.20) | 0.90 | 1.02 (0.65, 1.61) | 0.96 | 1.25 (0.74, 2.11) | 0.90 | 0.96 (0.64, 1.43) | 0.96 | 1.01 (0.62, 1.65) | 0.98 |
GG | Referent | Referent | Referent | Referent | Referent | |||||
rs2273535 | ||||||||||
TA + TT | 0.96 (0.78, 1.17) | 0.90 | 1.30 (0.87, 1.94) | 0.87 | 1.11 (0.71, 1.74) | 0.90 | 0.81 (0.58, 1.13) | 0.87 | 1.36 (0.92, 2.00) | 0.79 |
AA | Referent | Referent | Referent | Referent | Referent | |||||
rs2298016 | ||||||||||
CG + CC | 0.96 (0.79, 1.16) | 0.90 | 1.14 (0.77, 1.70) | 0.90 | 1.38 (0.90, 2.11) | 0.79 | 0.67 (0.48, 0.93) | 0.38 | 1.34 (0.93, 1.95) | 0.79 |
GG | Referent | Referent | Referent | Referent | Referent | |||||
rs6014711 | ||||||||||
AG + AA | 0.95 (0.77, 1.17) | 0.90 | 0.74 (0.47, 1.17) | 0.87 | 0.79 (0.48, 1.29) | 0.90 | 1.33 (0.97, 1.84) | 0.76 | 0.93 (0.61, 1.40) | 0.90 |
GG | Referent | Referent | Referent | Referent | Referent | |||||
rs6024840 | ||||||||||
GA + GG | 0.95 (0.78, 1.16) | 0.90 | 1.21 (0.80, 1.84) | 0.90 | 1.28 (0.80, 2.05) | 0.90 | 0.76 (0.54, 1.06) | 0.79 | 1.00 (0.66, 1.50) | 0.99 |
AA | Referent | Referent | Referent | Referent | Referent | |||||
rs6092309 | ||||||||||
AG + AA | 0.61 (0.41, 0.92) | 0.38 | 0.95 (0.43, 2.09) | 0.96 | 0.69 (0.29, 1.61) | 0.90 | 0.75 (0.44, 1.25) | 0.90 | 0.62 (0.32, 1.20) | 0.79 |
GG | Referent | Referent | Referent | Referent | Referent | |||||
rs6099122 | ||||||||||
GT + GG | 1.08 (0.81, 1.42) | 0.90 | 1.06 (0.58, 1.92) | 0.96 | 1.56 (0.86, 2.83) | 0.79 | 1.15 (0.77, 1.71) | 0.90 | 0.71 (0.44, 1.17) | 0.87 |
TT | Referent | Referent | Referent | Referent | Referent | |||||
rs6099126 | ||||||||||
TC + TT | 1.05 (0.79, 1.39) | 0.90 | 0.83 (0.45, 1.52) | 0.90 | 1.35 (0.73, 2.49) | 0.90 | 1.10 (0.73, 1.66) | 0.90 | 0.86 (0.53, 1.41) | 0.90 |
CC | Referent | Referent | Referent | Referent | Referent | |||||
rs6099128 | ||||||||||
GT + GG | 0.76 (0.60, 0.95) | 0.38 | 1.09 (0.70, 1.69) | 0.90 | 0.86 (0.52, 1.41) | 0.90 | 0.54 (0.37, 0.80) | 0.19 | 0.61 (0.38, 0.97) | 0.41 |
TT | Referent | Referent | Referent | Referent | Referent | |||||
rs1468055 | ||||||||||
AC + AA | 1.01 (0.81, 1.27) | 0.96 | 1.28 (0.82, 2.00) | 0.90 | 0.80 (0.46, 1.37) | 0.90 | 1.10 (0.75, 1.63) | 0.90 | 0.79 (0.48, 1.30) | 0.90 |
CC | Referent | Referent | Referent | Referent | Referent | |||||
rs6024836 | ||||||||||
AG + AA | 1.02 (0.82, 1.27) | 0.96 | 0.90 (0.58, 1.39) | 0.90 | 0.85 (0.52, 1.39) | 0.90 | 0.85 (0.59, 1.24) | 0.90 | 0.63 (0.41, 0.98) | 0.48 |
GG | Referent | Referent | Referent | Referent | Referent | |||||
rs2064863 | ||||||||||
AC + AA | 0.87 (0.69, 1.11) | 0.90 | 1.25 (0.76, 2.06) | 0.90 | 1.12 (0.64, 1.97) | 0.90 | 0.93 (0.61, 1.43) | 0.90 | 0.94 (0.56, 1.58) | 0.95 |
CC | Referent | Referent | Referent | Referent | Referent | |||||
rs6099119 | ||||||||||
GA + GG | 1.15 (0.68, 1.93) | 0.90 | 0.28 (0.04, 2.11) | 0.87 | 0.58 (0.13, 2.49) | 0.90 | 1.61 (0.85, 3.06) | 0.90 | 1.37 (0.62, 3.05) | 0.90 |
AA | Referent | Referent | Referent | Referent | Referent | |||||
rs911162 | ||||||||||
AG + AA | 0.83 (0.50, 1.40) | 0.90 | 0.85 (0.29, 2.47) | 0.93 | 0.87 (0.30, 2.55) | 0.95 | 1.32 (0.70, 2.51) | 0.90 | 0.68 (0.26, 1.79) | 0.90 |
GG | Referent | Referent | Referent | Referent | Referent |
Case-control odds ratio and 95% confidence interval adjusted for age, self-identified race, African ancestry and offset term.
False discovery rate (FDR) adjusted P-values.