Table 3.
Gene expression profiling studies of aging ocular tissues
| Organism | Tissue/cell type | Platform | Number of genes | Age range | Reference |
|---|---|---|---|---|---|
| Human | Neural retina/macula and periphery | SAGE | 320,998 tags | 44–88 yr | (Sharon et al., 2002) |
| Human | Neural retina | Microarray, Micromax | 2,400 probes | 13–72 yr | (Yoshida et al., 2002) |
| Human | Neural retina | Microarray, Custom | 10,034 genes | 29–90 yr | (Chowers et al., 2003a) |
| Human | Neural retina/macula and periphery | Microarray, Affymetrix Human Genome U133 plus 2 | 54,600 gene probes | 18–79 yr | (Cai et al., 2012) |
| Mouse | Neural retina | Microarray, Agilent Technologies, Whole Mouse Genome Oligo Microarrays 4x44K | 43,379 gene features | 3–20 mo | (Chen et al., 2010a) |
| Mouse - senescence | Neural retina | Microarray, Affymetrix MG_U74Av2 GeneChip | 36,000 full-length genes and EST clusters | 3–21 mo | (Carter et al., 2005) |
| Mouse | Rod photoreceptors (flow-sorted Nrlp-EGFP retina) | Microarray, Affymetrix Mouse Exon 1.0ST Array GeneChip | >28,000 coding, >7,000 non-coding transcripts | 1.5–12 mo | (Parapuram et al., 2010) |
| Mouse | Microglia (flow-sorted, CD11b-immunopositive cells) | Microarray, Affymetrix Mouse Exon 1.0ST Array GeneChip | >28,000 coding, >7,000 non-coding transcripts | 3–24 mo | (Ma et al., 2013) |
| Rat - senescence | Neural retina | RNA-Seq, Illumina GA IIx | 15,300 identified transcriptsa | 3–18 mo | (Kozhevniko va et al., 2013) |
a
Approximate number of transcripts detected in at least three samples with FPKM>1