Fig. 5.
Modulation of anti-DBPDE-induced DNA adducts in vitro using a non-enzymatic system consisting of salmon testes DNA incubated with anti-DBFDE (1 μM). Anti-DBPDE is the carcinogenic metabolite of DBP. Compounds tested (150 μM) were selected from the most effective agents identified from the micro-somal test system. DNA adducts were analyzed by 32P-postlabeling assay. Total adduct levels in the presence of test agents were compared to vehicle (corn oil + 20% DMSO) control and were significantly different if p < 0.05 (n = 3–5) (*p < 0.05; **p < 0.001; ***p < 0.0001).