Table III.
Studies of response to treatment to eliminate HP infection with Iron Deficiency (ID) or Iron Deficiency Anemia (IDA) among children
| Study | Study design | Age (Years) |
Sample size | Treatment group | Results |
|---|---|---|---|---|---|
| Choe et al. 1999 (59) South Korea | RCT (Double-blind) |
10-17 | 22 IDA cases, 18 controls | HP infection treatment with and without iron or placebo | Treatment of HP infection was associated with more rapid response to oral iron therapy as compared with the use of iron therapy alone. |
| Barabino et al. 1999 (71) Italy | Uncontrolled trial | 4-14 | 4 IDA cases | HP infection treatment with iron supplementation | Resolution of IDA only after Iron supplementation. |
| Choe et al. 2000 (60) South Korea | Uncontrolled trial | 15-17 | 13 IDA cases | HP infection treatment with iron supplementation | HP infection eradication along with iron supplementation could correct the refractory anemia among children. |
| Konno et al. 2000 (73) Japan | Uncontrolled trial | 13-15 | 6IDA cases | HP infection treatment without iron supplementation | Resolution of IDA. |
| Guan et al. 2002 (61) China | RCT | 13-19 | 14 IDA trial cases, 14 IDA controls | HP infection treatment with iron supplementation | Resolution of IDA. |
| Kostaki et al. 2003 (74)Greece | Uncontrolled trial | 9-13 | 3 IDA cases | HP infection treatment with or without Iron supplementation | In all cases, long-standing iron supplementation became effective only after eradication of HP. |
| Russo-Mancuso et al. 2003 (72) Italy | Uncontrolled trial | 4-18 | 9 unresponsive IDA cases | HP infection treatment with Iron supplementation | The eradication of HP was associated with stable normalization of iron stores. |
| Li et al. 2003 (62) China | RCT | 14-19 | 21 IDA cases, 20 controls | HP infection treatment with Iron supplementation | Resolution of IDA. |
| Kurekci et al. 2005 (75) Turkey | Uncontrolled trial | 6-16 | 18 IDA cases, 36 ID cases, 86 normal | HP infection treatment without iron supplementation | Complete recovery of ID and IDA could be achieved with HP eradication without iron supplementation in children with HP infection. |
| Lin et al. 2005 (63) China | RCT | 6-12 | 35 IDA trial cases, 33 IDA controls | HP infection treatment with iron supplementation | Iron supplementation together with anti-HP therapy is more effective than iron supplementation therapy alone. |
| Wang et al. 2005 (64) China |
RCT | 10-18 | 30 IDA trial cases, 20 IDA controls | HP infection treatment with iron supplementation | Resolution of IDA. |
| Gessner et al. 2006 (77) USA | RCT (Un-blinded) |
7-11 | 106 trial cases, 113 controls | HP infection treatment with iron supplementation | Treatment and resolution of HP infection did not improve isolated ID or mild IDA up to 14 months after treatment initiation. |
| Wang et al. 2006 (65) China |
RCT | 5-14 | 15 IDA trial cases, 14 IDA controls | HP infection treatment with iron supplementation | Resolution of IDA. |