Figure 5.

Dose-dependent changes in protein expression. Unsupervised hierarchical clustering was performed on linear load-corrected measurements of protein expression and a heatmap generated where relative protein expression is color-coded such that red indicates higher expression and green indicates lower expression. Rows represent patients and columns represent the ratio of post-treatment to pre-treatment expression for each protein. Patients 102 and 103 received a lower dose (400 mg) of sorafenib while patients 105, 107, 108 received a higher dose (600 mg) of sorafenib. Expression ratios are shown for the 35 proteins with P\0.10 in an unpaired t-test comparing low dose to high dose patients.