Table 1. Bivariate conditional logistic regression of risk factors for nosocomial C. difficile infection among hospitalized patients.
| Variable | Cases (n=75) |
Controls (n=150) |
OR (95% CI) | P value |
|---|---|---|---|---|
| Age, median years (IQR) | 60 (51-70) | 59 (49-70) | ---- | 0.66 |
| Female sex | 35 (47) | 73 (49) | 0.93 (0.54-1.56) | 0.78 |
| Non-white race | 18 (24) | 68 (45) | 0.37 (0.20-0.72) | 0.003 |
| Overweight/Obesityb | 59 (79) | 88 (59) | 2.74 (1.39-5.40) | 0.004 |
| Surgical service | 20 (27) | 49 (33) | 0.74 (0.39-1.38) | 0.34 |
| Single room | 66 (88) | 97 (65) | 3.74 (1.76-7.96) | 0.001 |
| Hospital room square footage, median (IQR) |
191 (191-244) | 180 (168-198) | 2.03 (1.40-2.94) | <0.001 |
| Hospital admission in the previous 90 days |
11 (15) | 9 (6) | 2.59 (1.04-6.50) | 0.04 |
| Comorbidities | ||||
| Chronic kidney disease | 5 (7) | 28 (19) | 0.31 (0.11-0.84) | 0.02 |
| Malignancy | 47 (63) | 59 (39) | 2.92 (1.56-5.47) | .001 |
| Pulmonary disease | 5 (67) | 17 (11) | 0.56 (0.20-1.58) | 0.27 |
| Cardiac disease | 12 (16) | 29 (19) | 0.79 (0.37-1.67) | 0.53 |
| Solid organ or hematopoietic stem cell transplant in prior 6 months |
3 (4) | 9 (6) | 0.64 (0.17-2.50) | 0.52 |
| Cirrhosis | 2 (3) | 8 (5) | 0.50 (0.10-2.35) | 0.38 |
| Cerebrovascular disease | 1 (1) | 8 (5) | 0.22 (0.27-1.87) | 0.17 |
| Medicationsc | ||||
| Cefepime | 39 (52) | 57 (38) | 1.94 (1.05-3.59) | 0.03 |
| Clindamycin | 7 (9) | 4 (3) | 3.50 (1.02-12.0) | 0.046 |
|
First-generation cephalosporin |
9 (12) | 36 (24) | 0.39 (0.16-0.92) | 0.03 |
| Corticosteroids | 45 (60) | 62 (41) | 2.14 (1.20-3.80) | 0.009 |
| Immunosuppressants | 17 (23) | 9 (6) | 5.70 (2.07-15.7) | 0.001 |
Abbreviations: OR, odds ratio; CI, confidence interval; IQR, interquartile range.
a
Data are presented as numbers (percentages) except where noted.
b
BMI ≥25.
c
Only variables with P<0.05 are shown.