Table 3.

Hazard ratios and 95% confidence intervals for associations between cancer subtypes diagnosed between 1993 and 2012, major depression, and minor depression in 1992.

Major depression (ref: everybody else)	Number of cancer morbidity at follow-up	Number with major depression	Major depression
			Unadjusted HR (95% CI)	Model 1	Model 2	Model 3	Model 4
Major depression
Men
Total cancer	49,744	3661	1.05 (1.02–1.09)	1.09 (1.06–1.13)	1.05 (1.02–1.09)	1.05 (1.02–1.09)	1.05 (1.01–1.09)
Prostate cancer (C61)	3811	260	1.01 (0.99–1.14)	1.07 (0.94–1.21)	1.12 (0.98–1.27)	1.12 (0.98–1.27)	1.13 (0.98–1.29)
Women
Total cancer	7860	751	0.93 (0.86–1.01)	0.92 (0.85–1.00)	0.93 (0.86–1.00)	0.93 (0.86–1.00)	0.90 (0.83–0.98)
Breast cancer(C50)	2244	234	1.00 (0.88–1.15)	1.00 (0.87–1.15)	1.00 (0.87–1.14)	1.00 (0.87–1.14)	0.98 (0.98–1.14)
Cervical cancer(C53)	588	141	0.73 (0.54–1.00)	0.72 (0.53–0.99)	0.72 (0.53–0.98)	0.72 (0.52–0.98)	0.63 (0.45–0.90)
Endometrial cancer (C54)	203	47	0.77 (0.46–1.29)	0.76 (0.45–1.27)	0.77 (0.46–1.30)	0.77 (0.46–1.30)	0.69 (0.39–1.21)
Ovarian cancer (C56)	300	75	1.11 (0.76–1.62)	1.10 (0.76–1.60)	1.10 (0.76–1.60)	1.11 (0.76–1.61)	1.03 (0.68–1.56)
Minor depression
Men
Total cancer	49,744	11,447	1.29 (1.26–1.31)	1.06 (1.04–1.09)	1.04 (1.01–1.06)	1.03 (1.01–1.06)	1.03 (1.01–1.06)
Prostate cancer (C61)	3811	983	1.48 (1.38–1.60)	1.11 (1.03–1.19)	1.13 (1.05–1.22)	1.14 (1.06–1.22)	1.13 (1.05–1.23)
Women
Total cancer	7860	1719	1.02 (0.97–1.08)	1.00 (0.95–1.06)	1.00 (0.95–1.06)	1.00 (0.95–1.06)	0.99 (0.93–1.05)
Breast cancer(C50)	2244	448	0.92 (0.82–1.02)	0.92 (0.83–1.02)	0.92 (0.83–1.02)	0.92 (0.83–1.02)	0.92 (0.82–1.03)
Cervical cancer(C53)	588	403	1.12 (0.92–1.36)	1.10 (0.91–1.33)	1.10 (0.91–1.33)	1.10 (0.91–1.33)	1.03 (0.84–1.27)
Endometrial cancer (C54)	203	140	1.07 (0.77–1.49)	1.07 (0.77–1.49)	1.08 (0.78–1.51)	1.08 (0.78–1.51)	1.11 (0.79–1.57)
Ovarian cancer (C56)	300	193	1.24 (0.95–1.62)	1.23 (0.94–1.61)	1.22 (0.94–1.60)	1.22 (0.94–1.60)	1.24 (0.93–1.64)

Model 1: adjusted for age, marital status, SES (demographics).

Model 2: adjusted for age, smoking status, alcohol drinking, exercise, BMl (demographics+health behaviors).

Model 3: adjusted for age, smoking status, alcohol drinking, exercise, BMI, cholesterol, blood sugar, hypertension (demos+health behaviors+biological indicators of subclinical illness).

Model 4: adjusted for age, smoking status, alcohol drinking, exercise, BMI, cholesterol, blood sugar, hypertension, and cancer family history (demos+health behaviors+biological indicators of subclinical illness + genetic liability).