(A) MicroRNA profiling in biopsies from pediatric UC patients (UC, n = 5) revealed a signature of deferentially regulated microRNAs, as compared to non-IBD pediatric patients (Control, n = 5). Heatmap representation and the fold-change in the relative levels of each deregulated microRNA (red indicates up-regulation, green down-regulation). (B) Real-time PCR for miR-4284 levels was performed in biopsies from pediatric patients with no-IBD (Control, n = 18) and with UC (n = 9). Data are presented as scatter plots, lines represent the mean. *p < 0.05, t-test, Prism6 (GraphPad Software Inc.).