Table 2.
Brain regions showing statistically significant altered LF/HF-ALFF in ANCOVA between HC and MDD groups.
| Brain regions (Brodmann areas) | Cluster size | MNI coordinates |
F values | |||
|---|---|---|---|---|---|---|
| X | Y | Z | ||||
| LF-ALFF | ||||||
| Left hippocampus (BA34) | 50 | −18 | −12 | −20 | HC>MDD | 12.74 |
| Left superior temporal gyrus (BA22) | 60 | −50 | −32 | 8 | HC>MDD | 16.56 |
| Right middle orbitofrontal cortex (BA10) | 51 | 42 | 50 | −14 | MDD>HC | 10.66 |
| Left dorsomedial prefrontal cortex (BA10,9) | 58 | −6 | 60 | 20 | MDD>HC | 15.90 |
| Right putamen | 39 | 26 | 1 | 16 | MDD>HC | 10.27 |
| Right caudate | 53 | 8 | 10 | 10 | MDD>HC | 12.53 |
| Right middle frontal gyrus (BA9) | 90 | 46 | 22 | 36 | MDD>HC | 17.12 |
| HF-ALFF | ||||||
| Left postcentral (BA 40,2) | 72 | −52 | −36 | 32 | HC>MDD | 21.19 |
| Left precentral (BA 6) | 41 | −28 | −12 | 62 | HC>MDD | 12.85 |
| Left paracentral (BA 5) | 87 | −4 | −42 | 68 | HC>MDD | 17.10 |
| Right pons | 46 | 16 | −38 | −32 | MDD>HC | 18.06 |
| Left thalamus | 58 | −2 | −22 | −16 | MDD>HC | 17.12 |
Abbreviations: ANCOVA: analysis of covariance; BA: Brodmann area; HC: healthy control; LF- and HF-ALFF: low frequency and high frequency amplitude of low-frequency fluctuation; MNI: Montreal Neurologic Institute; MDD: major depressive disorder.