Table 3.
Brain regions showing statistically significant correlation between LF/HF-fALFF and depression severity in terms of CES-D scores in subjects with MDD.
| Brain regions (Brodmann areas) | Cluster size | MNI coordinates |
R values | ||
|---|---|---|---|---|---|
| X Y | Z | ||||
| LF-ALFF | |||||
| Left mid occipital lobe (BA18, 19) | 191 | −60 | −72 | 10 | −0.73 |
| Left thalamus | 53 | −4 | −6 | 4 | −0.73 |
| Right precuneus (BA7) | 42 | 12 | −66 | 50 | −0.67 |
| Left postcentral (BA40) | 228 | −40 | −46 | 58 | −0.77 |
| Right postcentral (BA40) | 93 | 36 | −34 | 64 | −0.69 |
| Right anterior cingulate cortex (BA24,32) | 155 | 2 | 32 | 8 | +0.83 |
| Right superior temporal pole (BA38) | 93 | 30 | 16 | −38 | +0.72 |
| HF-ALFF | |||||
| Left postcentral (BA 40,2) | 182 | −44 | −40 | 52 | +0.77 |
| Right thalamus | 58 | 2 | −14 | 14 | +0.66 |
Abbreviations: BA: Brodmann area; CES-D: Center for Epidemiological Studies-Depression; LF- and HF-fALFF: low frequency and high frequency fractional of amplitude of low-frequency fluctuation; MNI: Montreal Neurologic Institute; MDD: major depressive disorder.