Table 3.

Significant disease related alterations in the intrinsic connectivity of the sensorimotor resting state network

Sensorimotor Network
Covariates										Controlling for Depression			Controlling for Anxiety
Contrast	Region	Hemisphere	BA	Z	p	k	X	Y	Z	Region	p	k	Region	p	k
LPVD > HC
	SMA	Left/Right	6	4.20	.008	55	0	6	58	SMA (Right)	.043	26
													PSC (Left)	.011	46
HC > LPVD
										PSC (Left)	.008	50	PSC (Left)	.087	46
LPVD > IBS
	SMA	Left/Right	6	5.84	4.07⁻⁷	305	−2	−24	52	SMA (Left/Right)	4.26⁻⁷	335	SMA (Left/Right)	4.65⁻⁷	319
	PMC	Left	6	5.41	1.84⁻⁶	259	−30	−22	62	PMC (Left)	1.74⁻⁶	287	PMC (Left)	1.23⁻⁶	291
	SMA	Right	6	4.25	.022	39	2	6	60	SMA (Right)	.022	39	SMA (Right)	.022	39
IBS > LPVD
	STC	Right	41, 42	6.80	.037	31	62	−8	6	STC (Right)	.037	31	STC (Right)	.037	31
	PSC	Left	3	6.03	1.09⁻⁵	208	−44	−14	32	PSC (Left)	1.31⁻⁴	192	PSC (Left)	1.45⁻⁴	197
	PSC	Right	4	5.88	.012	49	54	−6	34	PSC (Right)	.015	45	PSC (Right)	.014	46

Results from the whole brain contrast analyses and covariate analyses using the general linear model to test for group differences in intrinsic connectivity are presented here.We only report group differences significant at p<.05, corrected for family wise error using SPM8. We also report results for the analysis after controlling for depression and anxiety. Missing probability values for covariate analysis indicate the cluster did not achieved an uncorrected p value <.05 uncorrected. All regions are represented in Montreal Neurological Institute (MNI) space with X, Y, Z coordinates.

Abbreviations: BA, Brodmann's area; HC, healthy control; IBS, irritable bowel syndrome; k, number of voxels in the cluster; LPVD, localized provoked vulvodynia; PMC, primary motor cortex; p, probability value corrected for family wise error rate; PSC, primary somatosensory cortex; SMA, supplementary motor area; STC, superior temporal cortex