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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Pain. 2015 May;156(5):809–819. doi: 10.1097/01.j.pain.0000461289.65571.54

Table 4.

Significant disease related alterations in the intrinsic connectivity of the salience resting state network

Salience Network
Covariates Controlling for Depression Controlling for Anxiety
Contrast Region Hemisphere BA Z Cluster FWE p Cluster k X Y Z Region Cluster FWE p Cluster k Region Cluster FWE p Cluster k
LPVD >
HC
Globus
Pallidus		 Left 5.60 2.69−6 229 −
10		 2 6 Globus
Pallidus
(Left)		 .002 81 Globus
Pallidus
(Left)		 1.2=5 129
aMCC Left 24 5.41 2.79−5 173 −4 20 32 aMCC
(Left)		 2.61−5 169
Putamen Left 4.31 .018 49 −
14		 10 4 Putamen
(Left)		 .003 74
HC >
LPVD
omPFC Left/Right 10 4.90 4.93−6 214 0 60 −
12		 omPFC
(Right)		 4.98−6 281 omPFC
(Right)		 4.8−6 239
LPVD >
IBS
aMCC Left 24 6.18 1.49−14 843 −4 20 32 aMCC
(Left)		 1.61−14 864 aMCC
(Left)		 1.51−14 825
Globus
Pallidus		 Left 5.89 3.19−5 170 −
10		 0 6 Globus
Pallidus
(Left)		 2.49−5 159 Globus
Pallidus
(Left)		 2.45−5 149
Caudate
Nucleus		 Right 4.70 .008 61 12 18 0 Caudate
Nucleus
(Right)		 .004 69 Caudate
Nucleus
(Right)		 .007 51
IBS>LPVD
dmPFC Left 10 6.25 1.02−9 452 2 52 36 dmPFC
(Left)		 1.32−8 435 dmPFC
(Left)		 1.12−9 458
dmPFC Right 9 4.84 .001 101 14 52 36 dmPFC
(Right)		 .002 85 dmPFC
(Right)		 .001 90

Results from the whole brain contrast analyses and covariate analyses using the general linear model to test for group differences in intrinsic connectivity are presented here. We only report group differences significant at p<.05, corrected for family wise error using SPM8. We also report results for the analysis after controlling for depression and anxiety. Missing probability values for covariate analysis indicate the cluster did not achieved an uncorrected p value <.05 uncorrected. All regions are represented in Montreal Neurological Institute (MNI) space with X, Y, Z coordinates

Abbreviations: aMCC, anterior mid-cingulate cortex; BA, Brodmann's area; dmPFC, dorsal medial prefrontal cortex; HC, healthy control; IBS, irritable bowel syndrome; k, number of voxels in the cluster; LPVD, localized provoked vulvodynia; omPFC, orbital medial prefrontal cortex; p, probability value corrected for family wise error rate.