Table 5.

Significant disease related alterations in the intrinsic connectivity of the default mode resting state network

Default Mode Network (DMN)
Covariates										Controlling for Depression			Controlling for Anxiety
Contrast	Region	Hemisphere	BA	Z	Cluster FWE p	Cluster k	X	Y	Z	Region	Cluster FWE p	Cluster k	Region	Cluster FWE p	Cluster k
LPVD > HC
	Angular Gyrus	Left		7.65	7.67−11	542	− 48	− 64	32	Angular Gyrus (Left)	3.45−9	496	Angular Gyrus (Left)	2.45−9	326
	Angular Gyrus	Right		5.66	4.71−5	183	50	− 58	26	Angular Gyrus (Right)	2.21−4	163	Angular Gyrus (Right)	.004	77
	Anterior Precuneus	Right		6.76	2.22−16	1203	6	− 52	12	Precuneus (Right)	4.21−17	1244	Precuneus (Right)	1.98−14	792
HC > LPVD
	Posterior Precuneus	Right		7.01	8.19−7	300	14	− 64	36	Precuneus (Right)	2.98−6	306	Precuneus (Right)	4.98−6	250
	vPCC	Left	23, 31	5.67	.019	50	−4	− 38	22	vPCC (Left)	.023	45
	dPCC	Right	24	5.25	.024	46	4	− 24	28	dPCC (Left)	.021	47	dPCC (Left)	.057	28
LPVD > IBS
	Angular Gyrus	Left	39	7.48	2.62−9	496	− 48	− 64	32	Angular Gyrus (Left)	2.61−9	432	Angular Gyrus (Left)	1.51−9	443
	Angular Gyrus	Right	39	6.06	4.71−5	183	50	− 64	34	Angular Gyrus (Right)	3.49−5	144	Angular Gyrus (Right)	2.45−4	141
	Precuneus	Left		4.53	.012	58	−4	− 56	18	Precuneus (Left)	.046	35	Precuneus (Left)	.022	46
	Precuneus	Right		3.66	.037	39	16	− 54	16	Precuneus (Right)	.048	22	Precuneus (Right)	.042	23
IBS > LPVD
	dPCC/vPCC	Right	23, 31	6.33	9.15−6	228	4	− 36	26	dPCC/vPCC (Right)	8.32−7	251	dPCC/vPCC (Right)	1.12−7	249
	Precuneus	Right		4.93	1.06−6	292	6	− 72	50	Precuneus (Right)	1.32−6	312	Precuneus (Right)	4.42−6	315

Results from the whole brain contrast analyses and covariate analyses using the general linear model to test for group differences in intrinsic connectivity are presented here. We only report group differences significant at p<.05, corrected for family wise error using SPM8. We also report results for the analysis after controlling for depression and anxiety. Missing probability values for covariate analysis indicate the cluster did not achieved an uncorrected p value <.05 uncorrected. All regions are represented in Montreal Neurological Institute (MNI) space with X, Y, Z coordinates

Abbreviations: BA, Brodmann's area; dPCC, dorsal posterior cingulate cortex; HC, healthy control IBS, irritable bowel syndrome; k, number of voxels in the cluster; LPVD, localized provoked vulvodynia; p, probability value corrected for family wise error rate; vPCC, ventral posterior cingulate cortex.