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. Author manuscript; available in PMC: 2016 Apr 17.
Published in final edited form as: ACS Chem Biol. 2015 Jan 28;10(4):1072–1081. doi: 10.1021/cb500956g

Table 2.

SAR Studies of Modifying the Linker of UNC2170.a,b

ID R 53BP1 CBX7 JARID1A PHF1 PHF19 PHF23 UHRF1 L3MBTL1 L3MBTL3 MBTD1
7 graphic file with name nihms657957t8.jpg > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100
8 graphic file with name nihms657957t9.jpg > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100
9 graphic file with name nihms657957t10.jpg > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100
10 graphic file with name nihms657957t11.jpg > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100
11 graphic file with name nihms657957t12.jpg > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100
12 graphic file with name nihms657957t13.jpg > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100
13 graphic file with name nihms657957t14.jpg > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100 > 100
a

IC50 values are the average of at least 3 values ± the standard deviation as determined by AlphaScreen.

b

The maximum concentration in the assay was 100 µM and compounds showing less than 50% inhibition at this concentration are labeled >100 µM.