. Author manuscript; available in PMC: 2015 Apr 19.

Published in final edited form as: ACS Chem Biol. 2015 Jan 20;10(4):925–932. doi: 10.1021/cb500893q

Table 1.

Structures and IC₅₀ values of functionalized tetrahydropyridine PAFAH1b2 inhibitors. Inhibitors were screened by gel-based ABPP with FP-alkyne in mouse brain soluble proteomes doped with recombinant mouse PAFAH1b2 (1 μM). IC₅₀ values are reported as means and 95% confidence intervals from three independent experiments. Ts, tosyl.

Compound	IC₅₀ μM (95% C.I.)	Compound	IC₅₀ μM (95% C.I.)
B6	1.1 (0.6–2.4)	JW1036	> 10
F5	4.5 (2.3–7.1)	JW1038	9.3 (6.2–13.3)
H4	1.1 (0.2–3.2)	JW1039	> 50
J8	9.4 (7.1–14.8)	JW1041	1.7 (1.2–2.3)
J13	8.2 (5.8–12.3)	JW1043	7.5 (5.2–10.1)
K9	1.4 (1.1–2.0)	JW1058	4.6 (2.3–7.2)
O8	2.0 (1.3–2.8)	JW1061	7.6 (1.7–15.2)
P11	0.8 (0.4–1.6)	JW1068	> 10