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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: J Immunol. 2015 Mar 23;194(9):4130–4143. doi: 10.4049/jimmunol.1403023

Figure 5. GC B cell specific excision of B6 Ly108 and CD84 in Sle1b-BAC90 mice reinstates loss of tolerance to ANA.

Figure 5

(A–E) ELISPOT analysis of IgM-, IgG-, dsDNA-, histone-, and nucleosome-specific splenic AFCs in 4–5 mo old mice. (F–J) IgG2c specific antibodies against dsDNA, histone, nucleosome, Sm/RNP, cardiolipin, and IgG2b-specific antibodies against nucleosome were measured through ELISA. (K–O) ELISPOT analysis of IgM-, IgG-, dsDNA-, histone-, and nucleosome-specific long-lived bone marrow AFCs at 4–5 months. Each circle represents an individual mouse. *p <0.05, **p <0.01, ***p <0.001.