Figure 7.

Inhibition of hypertonic saline–evoked OOemg responses after synaptic blockade at the Vi/Vc transition or the Vc/C1 region. (A) Examples of inhibition of hypertonic saline–evoked OOemg activity in dry eye disease (DE) rats after CoCl₂ (0.3 μL, 100 mM) injection into the Vi/Vc transition (upper trace) or into the Vc/C1 region (lower trace). Scale bar = 30 seconds. (B) Summary of integrated OOemg responses to hypertonic saline in sham and 14d DE rats after synaptic blockade at the Vi/Vc transition (left panel) or at the Vc/C1 region (right panel). **P < 0.01 vs preinjection value; b = P < 0.01 vs sham. Sample sizes for Vi/Vc transition injections: sham-PBS, n = 5; sham-CoCl₂, n = 4; DE-PBS, n = 4, DE-CoCl₂, n = 5. Sample sizes for Vc/C1 region injections: sham-PBS, n = 4; sham-CoCl₂, n = 5; DE-PBS, n = 4, DE-CoCl₂, n = 5.