Table 4.

Unadjusted and Adjusted Associations Between Prehospital Vitamin D Status and HACDI in Patients With Confirmed Toxin A or B in Stool Samples (n = 568).

	Prehospital 25(OH)D
Association	<10 ng/mL	10–19.9 ng/mL	20–29.9 ng/mL	≥30 ng/mL
Unadjusted
OR (95% CI)	2.40 (0.86–6.69)	1.75 (0.66–4.75)	1.57 (0.54–4.55)	1.00 (Reference)
P value	.094	.21	.84
Adjusted
OR (95% CI)	2.90 (1.01–8.34)	2.14 (0.76–5.98)	1.70 (0.58–5.03)	1.00 (Reference)
P value	.048	.15	.34

CI, confidence interval; HACDI, hospital-acquired Clostridium difficile infection; OR, odds ratio; 25(OH)D, 25-hydroxyvitamin D. Unadjusted associations between 25(OH)D groups and HACDI were estimated by bivariable logistic regression models. Adjusted ORs were estimated by multivariable logistic regression models with inclusion of covariate terms thought to plausibly associate with both 25(OH)D concentrations and HACDI. Estimates adjusted for age, sex, race (nonwhite vs white), patient type (medical vs surgical), and Deyo-Charlson index.