Table 3.

Effect of proton pump inhibitors exposure on Helicobacter pylori detection, density and intestinal metaplasia following gastroesophageal reflux disease patients exclusion n (%)

	Previous PPI exposure n = 109	No PPI exposure n =143	P value
Gastritis
H. pylori gastritis	44 (40.40)	101 (70.60)
Inactive chronic gastritis	65 (59.60)	42 (29.40)	< 0.0001
H. pylori density
Low density	33 (75.0)	52 (51.50)
High density	11 (25.0)	49 (48.50)	0.010
Intestinal metaplasia	7 (6.40)	2 (1.40)	0.042

PPI: Proton pump inhibitor; H. pylori: Helicobacter pylori.