Table 1.
Patient demographics and disease characteristics n (%)
| Baseline | ETV (n = 159) | LAM (n = 146) |
| Age, mean ± SE, yr (range) | 35 ± 1.1 (17-76) | 34 ± 1.1 (16-71) |
| Male | 116 (73) | 104 (71) |
| Race | ||
| Asian | 92 (58) | 87 (60) |
| White | 64 (40) | 53 (36) |
| HBV genotype | ||
| A | 45 (28) | 41 (28) |
| B | 28 (18) | 28 (19) |
| C | 44 (28) | 36 (25) |
| D | 18 (11) | 23 (16) |
| F | 12 (8) | 5 (3) |
| Mixed | 4 (3) | 3 (2) |
| Indeterminate | 7 (4) | 8 (5) |
| Missing | 1 (< 1) | 2 (1) |
| Serum HBV DNA, mean ± SE, log10 IU/mL | 9.52 ± 0.16 | 9.66 ± 0.16 |
| Hepatic HBV cccDNA, mean ± SE, log10 copies/HGEq | 1.90 ± 0.11 | 2.0 ± 0.11 |
| Hepatic HBV DNA, mean ± SE, log10 copies/HGEq | 0.3 ± 0.05 | 0.4 ± 0.04 |
| ALT (U/L) | ||
| mean ± SE | 134.9 (9.84) | 132.8 (10.07) |
| Median (range) | 96.0 (23.0-915.0) | 90.0 (27.0-715.0) |
| International normalized ratio | 1.1 (0.01) | 1.1 (0.01) |
| Albumin (g/dL) | 4.3 (0.04) | 4.2 (0.04) |
| Total bilirubin (mg/dL) | 0.8 (0.03) | 0.8 (0.03) |
| Prothrombin time (s) | 13.2 (0.16) | 13.3 (0.16) |
| Knodell necroinflammatory score, mean ± SE | 7.8 ± 0.23 | 7.5 ± 0.24 |
| Ishak fibrosis score, mean ± SE | 2.4 ± 0.11 | 2.1 ± 0.11 |
CccDNA: Covalently closed-circular DNA; ETV: Entecavir; LAM: Lamivudine; HGEq: Human genome equivalent.