Table 4.
Top 10 canonical pathways altered by silica-specifically in NHBE (24 h)
| Rank | Canonical pathway |
|---|---|
| 1 | Salvage pathways of pyrimidine deoxyribonucleotides |
| 2 | TREM1 signaling |
| 3 | Aryl hydrocarbon receptor signaling |
| 4 | Interferon signaling |
| 5 | Hepatic fibrosis/hepatic stellate cell activation |
| 6 | Role of JAK family kinases in IL-6-type cytokine signaling |
| 7 | Role of pattern recognition receptors in recognition of bacteria and viruses |
| 8 | Altered T- and B-cell signaling in rheumatoid arthritis |
| 9 | Role of IL-17A in arthritis |
| 10 | IL-6 signaling |
Top 10 canonical pathways significantly enriched by alteration in gene expression by silica only as determined by core analysis of silica-specific gene changes in IPA.