Figure 1.

Restricted cubic spline plot for marine ω-3 PUFA intake in relation to risk of MSS and MSI-high colorectal cancers in the pooled cohorts of the Nurses’ Health Study (1984–2010) and Health Professionals Follow-up Study (1986–2010). Dash and hatched lines represent 95% confidence intervals. Multivariable model was adjusted for the same set of covariables as in Table 2. No spline variable was selected. P _linearity = .03 for MSI-high tumors and .28 for MSS tumors. All P values are two-sided. MSI = microsatellite instability; MSS = microsatellite-stable; PUFA = polyunsaturated fatty acids.