Table 3.
Spearman's correlations (P-values) between hepcidin/Cr and MCP-1/Cr, functional parameters and changes in morphometric variables in 224 subjects with T1D mellitus.
| Hepcidin/Cr | MCP-1/Cr | iGFR | AER | HbA1c | ΔiGFR | iGFR slope | ΔVv(Mes/glom) | ΔGBM width | ΔSv(PGBM/glom) | ΔVv(Int/cortex)a | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hepcidin/Cr | 1.0 |
0.372b (<0.001) |
0.125 (0.062) |
0.116 (0.085) |
−0.135 (0.043) |
0.023 (0.733) |
0.104 (0.123) |
0.089 (0.186) |
0.001 (0.989) |
−0.066 (0.326) |
0.070 (0.363) |
| MCP-1/Cr | 1.0 | 0.056(0.401) | 0.191(0.004) | 0.026(0.697) | 0.039 (0.562) |
0.090 (0.178) |
0.048 (0.471) | 0.066 (0.327) | −0.125 (0.061) | −0.016 (0.830) | |
| iGFR | 1.0 | 0.186 (0.005) | 0.135 (0.044) | −0.336 (<0.001) |
−0.222 (<0.001) |
−0.002 (0.980) | 0.152 (0.023) | −0.082 (0.222) | −0.004 (0.962) | ||
| AER | 1.0 | 0.196 (0.003) | −0.054 (0.422) |
0.018 (0.785) |
0.054 (0.424) | 0.072 (0.283) | −0.229 (0.001) | −0.102 (0.184) | |||
| HbA1c | 1.0 | −0.123 (0.068) |
−0.112 (0.097) |
0.153 (0.022) | 0.197 (0.003) | −0.213 (0.001) | 0.175 (0.022) | ||||
| ΔGFR | 1.0 |
0.688 (<0.001) |
0.018 (0.785) |
0.044 (0.511) |
−0.041 (0.540) |
0.110 (0.153) |
|||||
| GFR slope | 1.0 | 0.024 (0.721) |
0.088 (0.190) |
−0.084 (0.210) |
0.047 (0.543) |
||||||
| ΔVv(Mes/glom) | 1.0 | 0.223 (0.001) | −0.467 (<0.001) | −0.160 (0.036) | |||||||
| ΔGBM width | 1.0 | −0.264 (<0.001) | 0.047 (0.539) | ||||||||
| ΔSv(PGBM/glom) | 1.0 | −0.092 (0.229) | |||||||||
| ΔVv(Int/cortex)a | 1.0 |
P-values less than 0.05 are shown in bold.
AER, albumin excretion rate; HbA1c, glycosylated hemoglobin; GBM, glomerular basement membrane; iGFR, iohexol glomerular filtration rate; MCP-1/Cr, urinary monocyte chemoattractant protein-1/creatinine ratio; Sv(PGBM/glom), surface density of the peripheral glomerular basement membrane; Vv(Int/cortex), interstitial cortical fractional volume; Vv(Mes/glom), mesangial fractional volume per glomerulus.
aN = 172.
bPartialled for urine creatinine concentration. The correlation not partialled for urine creatinine concentration is r = 0.373, P < 0.001.