Table 6. Expression of gastric and intestinal epithelial markers and genetic alterations in adenocarcinoma.
|
Gastric epithelial markers |
Intestinal epithelial markers |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
MUC5AC |
MUC6 |
MUC2 |
CDX2 |
|||||||||
| 2+ | 1+ | 0 | 2+ | 1+ | 0 | 2+ | 1+ | 0 | 2+ | 1+ | 0 | |
|
GNAS | ||||||||||||
| Mutated | 5 | 0 | 0 | 2 | 2 | 1 | 0 | 1 | 4 | 0 | 2 | 3 |
| Wild type | 8 | 4 | 13 | 2 | 6 | 17 | 2 | 5 | 18 | 14 | 7 | 4 |
| P-value | 0.009 |
0.13 |
1.0 |
0.045 |
||||||||
|
KRAS | ||||||||||||
| Mutated | 5 | 1 | 5 | 2 | 2 | 7 | 0 | 2 | 9 | 3 | 4 | 4 |
| Wild type | 8 | 3 | 8 | 2 | 6 | 11 | 2 | 4 | 13 | 11 | 5 | 3 |
| P-value | 1.0 | 0.69 | 0.52 | 0.14 | ||||||||
The results of immunohistochemistry were scored as: +2, >50% positive cells; +1, 10%–50% positive cells; 0, <10% positive cells. P-values were assessed by Fisher's exact test (2+ vs 1+ or 0).