Table 3.
Interaction effects of statistical significance in ccRCC development revealed with binary logistic regression analysis.
| Interacting loci | Genes | OR (95% CI) for interaction model | P value for interaction model |
|---|---|---|---|
| rs4765623∗rs9679290 | SCARB1 ∗ EPAS1 | 1.371 (1.087–1.729) | 0.008 |
| rs7121∗rs9679290 | GNAS1 ∗ EPAS1 | 1.284 (1.047–1.575) | 0.016 |
| rs7121∗rs1805008 | GNAS1 ∗ MC1R | 2.601 (1.089–6.212) | 0.031 |
| rs7121∗rs2228570 | GNAS1 ∗ VDR | 1.240 (1.018–1.510) | 0.032 |
| MC1R “r”∗rs7975232 | MC1R ∗ VDR | 1.341 (1.020–1.763) | 0.035 |
| rs7121∗rs4765623 | GNAS1 ∗ SCARB1 | 1.639 (1.020–2.639) | 0.041 |