Table 5.
Performance of miR-16-5p and miR-19b-3p normalized to the exogenous miRNA in the differential diagnosis of GC cases with different TNM stages and differentiation grades from N controls in the total training and validation phases.
| h16c39 | h19bc39 | |||||||
|---|---|---|---|---|---|---|---|---|
| AUC (95%CI) |
Cutoff | Sensitivity | Specificity | AUC (95%CI) |
Cutoff | Sensitivity | Specificity | |
| T1 | 0.687 (0.583,0.792) |
7.335 | 0.788 | 0.532 | 0.634 (0.525,0.744) |
12.053 | 0.636 | 0.613 |
| T* | 0.648 (0.547,0.749) |
8.393 | 0.545 | 0.697 | 0.682 (0.579,0.785) |
12.275 | 0.755 | 0.515 |
| T2 | 0.761 (0.662,0.860) |
7.168 | 0.923 | 0.514 | 0.714 (0.606,0.823) |
11.903 | 0.769 | 0.586 |
| T3 | 0.815 (0.747,0.884) |
8.425 | 0.576 | 0.919 | 0.822 (0.759,0.886) |
11.863 | 0.915 | 0.586 |
| T4 | 0.832 (0.742,0.922) |
8.570 | 0.560 | 0.964 | 0.821 (0.738,0.904) |
11.878 | 0.920 | 0.586 |
| G1 | 0.777 (0.674, 0.880) |
7.543 | 0.941 | 0.613 | 0.692 (0.578,0.805) |
11.785 | 0.824 | 0.568 |
| G2 | 0.733 (0.650,0.816) |
8.425 | 0.500 | 0.919 | 0.719 (0.635,0.802) |
12.863 | 0.569 | 0.793 |
| G3 | 0.801 (0.734, 0.869) |
8.195 | 0.594 | 0.847 | 0.791 (0.723,0.859) |
11.903 | 0.859 | 0.586 |
| GC | 0.772 (0.716,0.827) |
8.368 | 0.490 | 0.910 | 0.749 (0.691,0.807) |
11.863 | 0.813 | 0.586 |