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. 2015 Jan 8;43(7):e44. doi: 10.1093/nar/gku1393

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Validation of sample-specific driver gene predictions. (a) Box plots depicting the distribution across samples of FPR for driver gene predictions in OncoIMPACT (average of 20 simulations). Decoy mutations were introduced in random genes as proxy for non-drivers in this assessment. (b) Overlap between predicted unique cell line-specific drivers and shRNA validated genes (using at least 2 shRNAs) ESP in 24 ovarian cancer cell lines. Number in parenthesis represent the number of unique genes. The P-value is computed using hypergeometric test. (c) Frequency in TCGA samples and mutation type for driver gene predictions from a melanoma sample. (d) Cell proliferation assay in a patient-derived melanoma cell line treated with control siRNA or siRNA targeting BRAF and TRIM24. Error bars represent SEM of three independent repeats. Statistical significance was assessed by using student's t-test.