Figure 2.

Cross-talk between different functional lncACTs and their network properties. (A) A global lncACT cross-talk network consisting of 335 lncRNAs, 212 miRNAs and 1312 mRNAs was constructed and are arranged as inner, intermediate and outer layers, respectively. Layers were connected through interactions, as seen from the high density of elements at layer interfaces. (B) Disease-associated genes mapped to the global network constituted nodes that exhibited specific topological characteristics compared to other nodes. In A and B, lncRNAs, miRNAs and coding-genes were blue, red and yellow colored. The node degree was indicated by the node size. Disease associated nodes were marked by black circles. (C) The network revealed a power law distribution with slope −1.32 and R² = 0.87. X axis indicating nodes degree distribution. Y axis indicating frequency of nodes according to X axis. (D and E) Disease-associated nodes had a higher degree and betweenness centrality than other nodes. Data are shown as mean ± SEM. Disease-associated and other nodes were indicated in red and blue along X axis. Average degrees of these two groups of nodes were indicated by Y axis.