Table 2.
Comparison of pharmacokinetic parameters (TAC, MMF, and steroid) between patients with and without dyslipidemia.
| Drug | Parameters | After one month | P | |
|---|---|---|---|---|
| With dyslipidemia | Without dyslipidemia | |||
| TAC | Dose/BW (mg/kg/day) | 0.17 ± 0.08 | 0.20 ± 0.10 | 0.679 |
| AUC0–12 (ng·hr/mL) | 170.0 ± 34.6 | 187.4 ± 46.3 | 0.457 | |
| C max (ng/mL) | 18.6 ± 4.7 | 21.1 ± 6.7 | 0.166 | |
| Trough | 9.2 ± 3.2 | 9.9 ± 3.3 | 0.518 | |
|
| ||||
| MMF | Dose/BW (mg/kg/day) | 25.9 ± 7.1 | 22.3 ± 6.9 | 0.012 |
| AUC0–12 (ng·hr/mL) | 46.0 ± 26.8 | 46.2 ± 18.7 | 0.611 | |
| C max (ng/mL) | 9.3 ± 5.5 | 9.0 ± 4.9 | 0.716 | |
| Trough | 3.9 ± 2.3 | 2.8 ± 1.7 | 0.192 | |
|
| ||||
| Steroid | Dose/BW (mg/kg/day) | 0.20 ± 0.05 | 0.19 ± 0.03 | 0.023 |
| AUC0–24 (ng·hr/mL) | 1051.1 ± 426.9 | 1059.1 ± 407.4 | 0.936 | |
| C max (ng/mL) | 130.9 ± 45.9 | 141.3 ± 46.5 | 0.375 | |
| Trough | 0.9 ± 2.6 | 2.4 ± 8.5 | 0.549 | |
Mann-Whitney U tests were employed to analyze continuous values between groups.
P values less than 0.05 were considered to be statistically significant.
Values are expressed as mean ± SD.
TAC, tacrolimus; MMF, mycophenolate mofetil; BW, body weight; AUC, area under the concentration-time curve; C max, maximal concentration.