Table 4.
Sensitivity analyses of changing one parameter in the MetS outcome with another covering the same trait. At the bottom CRF and waist circumference are compared against the same MetS outcome. For each comparison a cutoff point in z-score was chosen, which selected the same proportion of cases.
| Odds ratios (95% CI) for quartiles of fitness | ||||
|---|---|---|---|---|
| 1st quartile | 2nd quartile | 3rd quartile | 4th quartile | |
| MetS without fatness (TG + HOMA + BP − HDL) | 5.2 (3.8–7.2) | 2.0 (1.4–2.9) | 1.8 (1.2–2.6) | 1 (ref.) |
| MetS with waist | 19.5 (10.8–35.1) | 3.7 (2.0–7.1) | 2.7 (1.4–5.3) | 1 (ref.) |
| MetS with sum4skin | 30.0 (15.3–58.6) | 5.0 (2.4–10.3) | 3.2 (1.5–6.8) | 1 (ref.) |
| MetS with BMI | 21.8 (12.2–39.3) | 4.8 (2.5–9.0) | 2.7 (1.4–5.2) | 1 (ref.) |
| MetS with bioimpedance (%fat)∗ | 11.7 (5.2–26.6) | 2.2 (0.8–5.6) | 1.0 (0.3–3.0) | 1 (ref.) |
| MetS with waist circumference∗ | 10.9 (4.2–28.4) | 2.3 (0.8–6.9) | 1.6 (0.5–5.2) | 1 (ref.) |
|
| ||||
| MetS with HOMA | 19.5 (10.8–35.1) | 3.7 (2.0–7.1) | 2.7 (1.4–5.3) | 1 (ref.) |
| MetS with glucose | 13.0 (7.7–21.8) | 2.3 (1.3–4.3) | 1.2 (0.6–2.4) | 1 (ref.) |
|
| ||||
| MetS (TG + HOMA + sysBP + waist − HDL) | 18.3 (7.8–43.3) | 3.2 (1.2–8.6) | 2.6 (1.0–7.1) | 1 (ref.) |
| Adding leptin | 75.2 (18.2–309.8) | 7.6 (1.6–35.4) | 5.2 (1.1–25.0) | 1 (ref.) |
|
| ||||
| MetS (TG + HOMA + sysBP + waist − HDL) | 22.7 (10.8–47.7) | 3.1 (1.3–7.5) | 2.3 (0.9–5.6) | 1 (ref.) |
| Adding APOA1 | 19.8 (9.8–40.1) | 2.8 (1.2–6.4) | 2.0 (0.8–4.8) | 1 (ref.) |
| Adding APOB | 24.3 (10.4–56.7) | 4.5 (1.7–11.6) | 2.5 (0.9–7.0) | 1 (ref.) |
| Adding adiponectin | 13.5 (6.5–27.9) | 1.9 (0.8–4.9) | 2.0 (0.8–4.7) | 1 (ref.) |
| Adding CRP | 12.7 (7.4–21.7) | 2.8 (1.5–5.3) | 1.8 (1.0–3.5) | 1 (ref.) |
|
| ||||
| MetS (TG + HOMA + BP − HDL) against CRF quartiles# | 5.2 (3.8–7.2) | 2.0 (1.4–2.9) | 1.8 (1.2–2.6) | 1 (ref.) |
| MetS (TG + HOMA + BP − HDL) against waist quartiles# | 1 (ref.) | 1.1 (0.8–1.6) | 1.2 (0.9–1.7) | 4.1 (3.1–5.4) |
| Adding CRF against waist quartiles | 1 (ref.) | 1.8 (1.1–3.0) | 2.5 (1.5–4.1) | 14.8 (9.6–22.9) |
#These two analyses compare the strength between quartiles of fitness and quartiles of waist circumference against the same MetS outcome.
∗Data only available in CoSCIS, which is why estimates of quartiles of fitness in relation to MetS including waist circumference differ from analysis above.