Table 1.
Disease category | GWAS | Gene | SNP | Drug | Target | Overlapa | P-valueb | ATC codec |
---|---|---|---|---|---|---|---|---|
Cancer | 147 | 326 | 341 | 115 | 171 | 7 | 0.01 | L01 |
Cardiovascular | 52 | 177 | 202 | 230 | 273 | 5 | 0.06 | C |
Immune | 92 | 328 | 398 | 49 | 70 | 8 | 1.3 × 10-5 | L03, L04 |
Metabolic | 90 | 601 | 561 | 146 | 185 | 13 | 2.0 × 10-3 | A02, A03, A04, A05, A06, A07, A10 |
Nervous | 74 | 162 | 178 | 314 | 248 | 3 | 0.18 | N |
Total | 450 | 1,344 | 1,586 | 827 | 719 | 95 | 1.6 × 10-11 |
aThe number of common genes between disease genes and drug target genes for each disease category.
bThe P-value was calculated by hypergeometric test on the common genes between disease genes and target genes compared with the human protein-coding genes for each disease category. cThe detail information for each ATC code was included in the Materials and methods.