Table 4. Comparison of clinical indicators observed in West Midlands series.
| Clinical indicator | All cases (n=212) | Causative variant identified (Test+ve n=44) | No causative variant identified and ≥ 1 germline test (Test−ve n=67) | No causative variant identified (n=168) |
|---|---|---|---|---|
| Mean age at tumour diagnosis | 46.2 SD 10.2 | 44 SD 10.9 | 46 (SD 9.8, P=0.3271) | 46.8 (SD 9.9 1.85, P=0.0643) |
| Mean age diagnosis first tumour | 42.5 SD 11.3 | 39.4 SD 12.3 | 42.9 (SD 10, P=0.1141) | 43.1 (SD 10.7, P=0.3681) |
| Mean age diagnosis second or synchronous tumour | 49.6 SD 7.4 | 48.1 SD 6.8 | 49.2 (SD 8.4, P=0.4473) | 50.1 (SD 7.2, P=0.0891) |
| Mean individual age at tumour diagnosis | 46.2 SD 8.4 | 44.2 SD 8.6 | 46 (SD 8.6, P=0.2801) | 46.7 (SD 8.3, P=0.0819) |
| % cases with individual mean age at tumour diagnosis ≤ Test+ve group median (46.25) | N/A | N/A | 41.8 (28) | 39.9 (67) |
| % cases with concordant tumour in first degree relative | 52.3 (111) | 63.6 (28) | 56.7 (38) (P=0.4654) | 49.4 (83) (P=0.09296) |
| Mean multiple tumour score | 14.6 SD 8.7 | 21 SD 14.3 | 14.1 (SD 5.4, P= <0.01) | 12.9 (SD 5.6, P= <0.01) |
| % cases with multiple tumour score ≥ Test+ve group median (17) | N/A | N/A | 28.3 (19) | 21.4 (36) |
Mean individual age at diagnosis=Combined age of tumours/number of tumours in individual.
P-values describe two-tailed comparison with Mut+ group (H0=μ1=μ2).