Figure 6.

Sleep deprivation during a critical window of brain development increases seizure susceptibility in adults. (A) No difference was observed in Cs flies tested for seizure activity after 12 h sleep deprivation when they eclosed (Day-0), or when they were mature on Day-3 and assessed for seizure after 3-d of recovery (n = 32 flies/group). (B) Immature sesb^9Ed-4/+ were sleep deprived for 12 h when they eclosed (Day-0), or when they were mature on Day-3 and assessed for seizure after 3-d of recovery (n = 30–50 flies/group). Sleep deprivation did not alter seizure susceptibility in mature sesb^9Ed-4/+. In contrast, when immature sesb^9Ed-4/+ flies were sleep deprived they continued to display increased susceptibility to seizure 3 days later. *P < 0.05 modified Bonferroni test.