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. Author manuscript; available in PMC: 2015 Apr 20.
Published in final edited form as: Cancer Res. 2007 Oct 15;67(20):10019–10026. doi: 10.1158/0008-5472.CAN-07-2354

Figure 3.

Figure 3

IL-1R−/−, but not IL-1Ra−/−, mice have reduced lung metastases. BALB/c, IL-1R−/−, and IL-1Ra−/− mice were inoculated with 7,000 4T1 tumor cells in the abdominal mammary gland on day 0, and their lungs harvested on days 35 to 40, when BALB/c mice were moribund. Metastatic cells were quantified using the clonogenic assay. Lung metastases are reduced in IL-1R−/− mice relative to BALB/c mice (P < 0.05). ●, number of metastatic cells in the lungs of individual mice. Data are pooled from two to three experiments.