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. Author manuscript; available in PMC: 2015 May 13.
Published in final edited form as: Nature. 2014 Oct 29;515(7526):209–215. doi: 10.1038/nature13772

Extended Data Figure 2. Expected number of ASD genes discovered as a function of sample size.

Extended Data Figure 2

The Multiple LoF test (red) is a restricted version of TADA that uses only the de novo LoF data. TADA (blue) models de novo LoF, de novo Mis3, LoF variants transmitted/not transmitted and LoF variants observed in case/control samples. The sample size (N) indicates either (i) N trios, for which we record de novo and transmitted variation, or (ii) N trios, for which we record only de novo events, plus N cases and N controls.