Table 1.
ASD risk genes1.
| dnLoF2 count | q≤0.01 | 0.01<q≤0.05 | 0.05<q≤0.1 |
|---|---|---|---|
| ≥2 | ADNP, ANK2, ARID1B, CHD8, CUL3, DYRK1A, GRIN2B, KATNAL2, POGZ, SCN2A, SUV420H1, SYNGAP1, TBR1 | ASXL3, BCL11A, CACNA2D3, MLL3 | ASH1L |
| 1 | CTTNBP2, GABRB3, PTEN, RELN | APH1A, CD42BPB, ETFB, NAA15, MYO9B, MYT1L, NR3C2, SETD5, TRIO | |
| 0 | MIB1 | VIL1 |
1
TADA analysis of loss-of-function (LoF) and damaging missense variants found to be de novo in ASD subjects, inherited by ASD subjects, or in ASD subjects (versus control subjects).
2
De novo LoF events.