Changes in the expression of bile acid detoxification enzymes Cyp3a, Ugt2b, Sult2a1, Gsta1-4, Gstm1-4, Cyp8b1, and Cyp27a1 in rats-treated with oleanolic acid. SD rats were given 100 mg/kg of oleanolic acid by gavage daily for 7 days. A. The mRNA expression of Cyp3a, Ugt2b, Sult2a1, Gsta2-a4, and Gstm1-4. B. The protein levels of Cyp3a, Ugt2b, Sult2a1, Gsta1-4, and Gstm1-4 analyzed by densitometry of the Western blotting (% of control group). C. Representative Western blots. *P < 0.01; #P < 0.05 vs the vehicle control; n = 5 rats per group. C, the control group; O, the oleanolic acid group.