Changes in the expression of nuclear receptors and transcriptional factors in rats-treated with oleanolic acid. SD rats were treated with oleanolic acid via gastric gavage at 100 mg/kg daily for 7 days. A. The mRNA expression of nuclear receptors Fxr, Shp, Pxr, Car, Vdr, Pparα, Hnf1α, Hnf4α, Rxrα, Rarα, Lxr, and Lrh-1, and transcriptional factors Nrf2, Hnf3β, and Ahr. B. Representative Western blots for Fxr, Shp, Pxr, Car, Vdr, Pparα, Hnf1α, Hnf4α, Rxrα, Rarα, Lxr, and Lrh-1and transcriptional factors, Nrf2, Hnf3β, and Ahr. C. Densitometry analysis of Western blots (% of control group). *P < 0.01; #P < 0.05 vs the vehicle control; n = 5 rats per group; C, the control group; O, the oleanolic acid group.