Table 2.

Cox univariate analysis for 3-year survival and 3-year disease-free survival in 95 patients who underwent esophageal resection for squamous cell carcinoma

	Univariate analysis
	3-year overall survival			3-year disease-free survival
	HR	95% CI	P-value	HR	95% CI	P-value
CAFs density			0.039			0.405
CAF-poor	1.000	Ref.	-	1.000	Ref.	-
CAF-rich	1.870	1.033-3.385	0.039	1.258	0.733-2.160	0.405
Differentiation grade			0.558			0.470
Well	1.000	Ref.	-	1.000	Ref.	-
Moderate	1.450	0.699-3.009	0.318	1.303	0.660-2.575	0.446
Poor	1.456	0.658-3.207	0.351	1.573	0.763-3.243	0.219
Tumor location			0.359			0.426
Upper	1.000	Ref.	-	1.000	Ref.	-
Middle	2.046	0.767-5.460	0.153	0.780	0.327-1.866	0.577
Low	1.296	0.659-2.550	0.452	0.558	0.213-1.464	0.236
pN status			0.041			0.100
pN0	1.000	Ref.	-	1.000	Ref.	-
pN1	1.772	0.900-3.491	0.098	1.317	0.693-2.504	0.401
pN2	2.534	1.121-5.729	0.025	2.034	0.922-4.486	0.078
PN3	3.557	1.060-11.938	0.040	3.450	1.042-11.427	0.043
pTNM stage			0.012			0.072
I	1.000	Ref.	-	1.000	Ref.	-
II	7.830	1.053-58.244	0.044	1.442	0.586-3.550	0.426
III	13.730	1.854-101.702	0.010	2.441	0.989-6.025	0.053
Radicality			0.048			0.070
R0	1.000	Ref.	-	1.000	Ref.	-
R1	3.424	0.813-14.432	0.094	2.363	0.568-9.837	0.237
R2	7.154	0.933-54.842	0.058	8.296	1.069-64.351	0.043
Adjuvant therapy			0.449			0.215
No	1.000	Ref.	-	1.000	Ref.	-
Yes	1.252	0.700-2.236	0.449	1.412	0.818-2.438	0.215

Abbreviations: N, pathological node stage; TNM, tumor node metastasis; CAFs, Cancer-associated fibroblasts; HR, hazard ratio; CI, confidence interval. Analysis was performed using the Cox proportion hazard model. P-value < 0.05 was considered significant.