Figure 1.

Baicalin cream inhibits DNFB-induced CHS reaction. Mouse were sensitized twice on the flank and challenged on the dorsal ear surfaces with DNFB. Topical treatments were performed twice daily for 2 consecutive days. Mouse exposed to baicalin cream displayed a reduced CHS response compared with negative control and vehicle-treated animals. Increased ear thickness, increased ear weight, thymus index, and spleen index were dose-dependently decreased. Data are expressed as mean ± SD (n = 8). *P < 0.05 as compared with the negative control group.