Figure 3.

Keratinocyte differentiation-modulating action of baicalin cream in mouse tail test. Topical treatment were performed twice daily for 4 consecutive weeks. Mice exposed to baicalin cream displayed an increased orthokeratosis response compared with vehicle-treated animals, indicative of the keratinocyte differentiation-inducing activity. Their orthokeratosis of granular layer, drug activity, and relative epidermal thickness were dose-dependently increased. Data are expressed as mean ± SD (n = 8). *P < 0.05 compared with vehicle cream.