Table 2.
Meta-analysis of the association between RAD51 G135C polymorphism and breast cancer risk
| Subgroups (No. Of studies) | GG vs. CC | GG + GC vs. CC | GG vs. GC + CC | G vs. C | GC vs. CC | |||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| OR (95% CI) | P-het | OR (95% CI) | P-het | OR (95% CI) | P-het | OR (95% CI) | P-het | OR (95% CI) | P-het | |
| Ethnicity | ||||||||||
| Asian (n = 4) | 0.96 (0.83, 1.12) | 0.203 | 0.96 (0.84, 1.09) | 0.101 | 1.07 (0.93, 1.24) | 0.080 | 1.01 (0.91, 1.11) | 0.015 | 0.83 (0.64, 1.08) | 0.075 |
| European (n = 8) | 1.00 (0.96, 1.04) | 1.000 | 1.00 (0.96, 1.04) | 1.000 | 1.00 (0.96, 1.04) | 0.952 | 1.00 (0.97, 1.03) | 0.998 | 1.00 (0.90, 1.11) | 0.990 |
| American (n = 3) | 1.01 (0.88, 1.15) | 0.988 | 1.01 (0.89, 1.14) | 0.990 | 1.00 (0.89, 1.14) | 0.979 | 1.01 (0.92, 1.10) | 0.970 | 1.05 (0.76, 1.45) | 0.939 |
| Source of control | ||||||||||
| Hospital (n = 2) | 0.99 (0.86, 1.13) | 0.956 | 0.99 (0.88, 1.12) | 0.959 | 1.01 (0.88, 1.15) | 0.806 | 1.00 (0.91, 1.09) | 0.904 | 0.94 (0.70, 1.25) | 0.933 |
| Population (n = 7) | 1.00 (0.93, 1.08) | 1.000 | 1.00 (0.94, 1.07) | 1.000 | 0.98 (0.91, 1.05) | 0.943 | 0.99 (0.95, 1.04) | 0.994 | 1.04 (0.89, 1.22) | 0.984 |
| Total (n = 15) | 1.00 (0.96, 1.04) | 0.987 | 1.00 (0.96, 1.03) | 0.946 | 1.00 (0.96, 1.04) | 0.769 | 1.00 (0.97, 1.03) | 0.656 | 0.98 (0.89, 1.07) | 0.778 |
CI: confidence interval; OR, odds ratio.