Skip to main content
. 2015 Mar 18;28(2):337–418. doi: 10.1128/CMR.00117-14

TABLE 2.

Effect of efflux pump gene inactivation on antibiotic MICsa

Agent MIC (μg/ml)
P. aeruginosa PAO1
 E. coli K-12
Wild type mexA::tet Wild type ΔacrAB
Norfloxacin >8 1 0.004 0.004
Ciprofloxacin 2 0.1 0.01 0.0025
Levofloxacin 0.25b 0.015b 0.063c 0.016c
Besifloxacin 1d 0.06d 0.25d 0.015d
Moxifloxacin 0.8e 0.05e
Tetracycline 8–16 0.5f 1.25 0.156
Tigecycline 8g 0.25g 0.5h 0.125h
Chloramphenicol 16 4 6.25 0.78
Novobiocin 128 16 100 1.56
Erythromycin 512i 64i 50 1.56
Azithromycin 100 6.25 8j 0.5j
Benzylpenicillin >1,024 512 16k 8k
Cloxacillin 5,120l 2.56l 256k 2k
Ampicillin 12.5 3.12
Carbenicillin 32 0.25 4k 1k
Azlocillin 4 0.5 16k 4k
Piperacillin 3m 0.4m 4c 0.25c
Cefoperazone 4 0.5 0.03k 0.015k
Ceftriaxone 64 8 0.0015k 0.0015k
Cefepime 2 1 0.0075k 0.0075k
Cefpirome 4 2 0.015k 0.015k
Imipenem 2 1–2 0.12k 0.12k
a

The MIC data for P. aeruginosa are from reference 13, and those for E. coli are from reference 27, unless otherwise indicated.

b

Data from reference 411, where a mexAB-oprM mutant was used.

c

Data from reference 95.

d

Data from reference 1009, where an oprM mutant was used for P. aeruginosa.

e

Data from reference 392.

f

Because the mutant strain contains the tet marker, the value for an oprM mutant is used (13).

g

Data from reference 393.

h

Data from reference 138.

i

Data from reference 187.

j

X.-Z. Li, unpublished data.

k

Data from reference 188.

l

Data from reference 390, where a mexAB-oprM mutant was used.

m

Data from reference 391, where an oprM mutant was used.