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The future TB clinic. Sputum, saliva, and fecal samples are collected from patients for genome sequencing, SNP typing, or metagenomic profiling to identify the presence of M. tuberculosis; provide strain identification and epidemiological information; identify genetic susceptibility to drug toxicity, drug pharmacokinetics, and susceptibility to reactivation of latent TB; and describe the patient-specific microbiome and its potential for oral drug biotransformation after digestion.
