TABLE 1.

Correlation coefficients of resistance to different drugs used to treat Streptococcus pneumoniae infections in the United States^a

Period (n)	Drug	Correlation coefficentb
		ERY	TET	CLI	SXT	TAX	CAZ	LVX
Pre-PCV7 (7,571)	PEN	0.610***	0.370***	0.266***	0.700***	0.454***		0.037**
	ERY		0.427***	0.399***	0.574***	0.311***		0.015
	TET			0.574***	0.338***	0.173***		0.009
	CLI				0.229***	0.078***		0.037**
	SXT					0.397***		0.029*
	TAX							0.021
Intermediate PCV7 coverage (16,735)	PEN	0.613***	0.359***	0.288***	0.626***	0.437***	0.299***	0.026***
	ERY		0.427***	0.440***	0.559***	0.369***	0.291***	0.045***
	β-TET			0.668***	0.321***	0.230***	0.291***	0.052***
	CLI				0.234***	0.198***	0.301***	0.040***
	SXT					0.389***	0.277***	0.035***
	TAX						0.727***	0.026***
	CAZ							−0.011
High PCV7 coverage (6,785)	PEN	0.579***	0.460***	0.422***	0.576***	0.440***	0.326***	0.030*
	ERY		0.565***	0.577***	0.588***	0.443***	0.338***	0.049***
	TET			0.819***	0.399***	0.516***	0.415***	0.026*
	CLI				0.343***	0.516***	0.393***	0.035**
	SXT					0.454***	0.336***	0.045***
	TAX						0.727***	0.014
	CAZ							0.019

^aPCV7, 7-valent pneumococcal conjugate vaccine; PEN, penicillin; ERY, erythromycin; TET, tetracycline; CLI, clindamycin; SXT, trimethoprim-sulfamethoxazole; TAX, cefotaxime; CAZ, ceftazidime; LVX, levofloxacin.

^b***, P < 0.001; **, P < 0.01; *, P < 0.1.