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. 2015 Apr 20;5:9846. doi: 10.1038/srep09846

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A: control group with folding index value 116. B: 300-second group with folding index value 728. C: 30-second group with folding index value 244. D: 60-second group with folding index value 331. E: 120-second group with folding index value 590. White contours were the extracted contours of a given ROI using the image processing approach.