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. 2015 Mar 10;7(4):438–449. doi: 10.15252/emmm.201404580

Figure 1. The side chain structure of CY enhances nitrogen mustard activity in cancer cells.

Figure 1

  1. Chemical structures of bendamustine, CY, compound A, and compound B (referred to as Cpd A and Cpd B hereafter).
  2. Growth inhibitory concentration (GI50) of CY and bendamustine in the NCI60 cell line panel.
  3. Nontoxic dose of Cpd A enhances bendamustine cytotoxicity in cancer cells. Images were taken at 48 h posttreatment.
  4. Cpd A augments DNA damage caused by bendamustine. H1650 cells were treated with 100 μM Bend, 50 μM Cpd A, 100 μM Bend plus 50 μM Cpd A, or 10 μM CY for 12 h, and cell lysates were blotted for γ-H2AX. Actin was used as a loading control.

Source data are available online for this figure.