Skip to main content
. 2015 Feb 27;172(9):2343–2353. doi: 10.1111/bph.13060

Figure 6.

Figure 6

Diagram illustrating the canonical visual cycle in human retina. Photon absorption by the visual chromophore triggers the isomerization from 11-cis-retinal (11cRAL) to all-trans-retinal (atRAL). atRAL is then reduced to atROL in the rod outer segments (ROS). atROL then travels from photoreceptors to the RPE across the IPM in the presence of the IRBP or RBP3. We propose that after moving across the RPE membrane with the assistance of OATP1A2, atROL is transformed into 11cRAL, which exits the RPE and travels back to the ROS to form new functional visual pigment.