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. 2015 Mar 26;172(9):2354–2368. doi: 10.1111/bph.13061

Figure 5.

Figure 5

TrkB activation after LTP induction was abolished in the MPTP model, and was restored by memantine (M) pretreatment. (A) A representative image of p-TrkB after TBS. (B) Summary data of the mean fluorescence intensity (MFI) around stimulus electrode. The data presented are means ± SEM (n = 5). *P < 0.05 compared with corresponding basal level; $P < 0.05 compared with TBS in MPTP group; two-way anova followed by Bonferroni test. (C) Representative images of apical dendrite. Green: PSD95, Red: p-TrkB. (Scale bar: 5 μm). (D) p-TrkB positive synapses were significantly increased after LTP induction compared with baseline in control group. In MPTP group, p-TrkB positive synapses after TBS was not obviously increased. Memantine pretreatment reversed the defect caused by MPTP. (E) KCl depolarization was applied to activate BDNF expression and TrkB activation in hippocampal slices from different groups. Representative blots of BDNF and p-TrkB are shown. (F) Summary data of BDNF expression after different drug treatment. (G) Summary data of p-TrkB/TrkB after different drug treatment. The data presented are means ± SEM. In each group, three slices from each animal and a total of 5 animals were used. *P < 0.05 compared with corresponding basal level; $P < 0.05 compared with MPP+ group after KCl depolarization; two-way anova followed by Bonferroni test.