Figure 5.

Effects of pimobendan treatment on up- and down-regulation of Ca²⁺ handling proteins and MyHC isoform transition in LV myocardium of DCM mice during progression of HF. (A) Effects of pimobendan treatment on the expression levels of SERCA2a and NCX1 (n = 3–5 mice per group). (B) Effects of pimobendan treatment on the relative expression level of β-MyHC isoform (n = 3–5 mice per group). *P < 0.05; **P < 0.01 versus the value before treatment; one-way anova and post hoc Dunnett's comparison test.